They only detract from the game for the vast majority of players. A few die-hards might soldier on no matter what if they are on some sort of purist playthrough, but generally, the only meaning they have is that the player must reload a previous save. I think at least these two need to go:
The caster's sex is changed
Gold on the caster is destroyed
Others, like the caster being polymorphed, are also likely candidates.
The caster's sex is changed
Gold on the caster is destroyed
Others, like the caster being polymorphed, are also likely candidates.